{"id":124204,"date":"2025-10-12T09:36:12","date_gmt":"2025-10-12T09:36:12","guid":{"rendered":"https:\/\/kamucalisani.net\/?p=124204"},"modified":"2025-10-12T09:36:12","modified_gmt":"2025-10-12T09:36:12","slug":"dunyanin-en-ilginc-ignesi-gelistirildi-isitme-kaybi-tedavilerinde-devrim","status":"publish","type":"post","link":"https:\/\/kamucalisani.net\/index.php\/2025\/10\/12\/dunyanin-en-ilginc-ignesi-gelistirildi-isitme-kaybi-tedavilerinde-devrim\/","title":{"rendered":"D\u00fcnyan\u0131n en ilgin\u00e7 i\u011fnesi geli\u015ftirildi: \u0130\u015fitme kayb\u0131 tedavilerinde devrim"},"content":{"rendered":"

<\/span> T\u0131p d\u00fcnyas\u0131 ve m\u00fchendislik alan\u0131nda \u00e7al\u0131\u015fan bir ekip, on y\u0131l\u0131 a\u015fk\u0131n s\u00fcredir y\u00fcr\u00fctt\u00fc\u011f\u00fc ara\u015ft\u0131rmalar sonucu i\u015fitme kayb\u0131 ve i\u00e7 kulak rahats\u0131zl\u0131klar\u0131n\u0131n tedavisinde devrim yaratacak bir mikroi\u011fne <\/strong>geli\u015ftirdi. <\/figure>\n

Columbia \u00dcniversitesi<\/strong>\u2019nden Kulak Burun Bo\u011faz (KBB) cerrah\u0131 Dr. Anil Lalwani ve makine m\u00fchendisi Jeffrey Kysar taraf\u0131ndan tasarlanan bu yenilik\u00e7i cihaz, i\u00e7 kula\u011f\u0131n hassas b\u00f6lgelerine ula\u015fmada \u00e7\u0131\u011f\u0131r a\u00e7an bir \u00e7\u00f6z\u00fcm sunuyor.<\/p>\n

\u0130\u015fitme kayb\u0131na yenilik\u00e7i tedavi<\/b><\/p>\n

Mikroi\u011fne teknolojisi, \u00f6zellikle koklea<\/strong> ad\u0131 verilen spiral \u015feklindeki i\u00e7 kulak yap\u0131s\u0131nda yer alan, i\u015fitmeden sorumlu h\u00fccrelere zarar vermeden tedavi ula\u015ft\u0131rmay\u0131 ama\u00e7l\u0131yor. Lalwani, bu bulu\u015fun \u00f6nemini \u015fu s\u00f6zlerle ifade ediyor: \u201cMikroi\u011fnemizin i\u00e7 kulak i\u00e7in hassas t\u0131bb\u0131n anahtar\u0131 olabilece\u011fini s\u00f6ylemek abart\u0131 olmaz\u201d<\/em><\/p>\n

<\/span> Bir gen terapisi vekt\u00f6r\u00fcn\u00fcn (alt s\u0131ra) ve bir kontrol sol\u00fcsyonunun (\u00fcst s\u0131ra) mikroi\u011fne yoluyla enjeksiyonundan sonra kokleadaki h\u00fccreler.<\/em> <\/figure>\n

Koklea, yaln\u0131zca 2 milimetre geni\u015fli\u011finde olan ve y\u0131rt\u0131lmas\u0131 durumunda kal\u0131c\u0131 i\u015fitme kayb\u0131 ve denge sorunlar\u0131na yol a\u00e7an bir zarla \u00e7evrilidir. Geleneksel cerrahi aletlerin bu zara zarar verme riski, yeni tedavilerin uygulanmas\u0131n\u0131 g\u00fc\u00e7le\u015ftiriyordu. Bu mikroi\u011fne sadece tedavi sunmakla kalmay\u0131p, kokleadan s\u0131v\u0131 \u00f6rne\u011fi alarak Meniere hastal\u0131\u011f\u0131<\/strong> gibi rahats\u0131zl\u0131klar\u0131n daha iyi anla\u015f\u0131lmas\u0131n\u0131 ve tedavi edilmesini de kolayla\u015ft\u0131racak.<\/p>\n

Lalwani ve Kysar\u2019\u0131n i\u015f birli\u011fi, yakla\u015f\u0131k 12 y\u0131l \u00f6nce, ortak \u00e7al\u0131\u015fan iki doktora sonras\u0131 ara\u015ft\u0131rmac\u0131n\u0131n tan\u0131\u015fmas\u0131yla ba\u015flad\u0131. Kysar, i\u00e7 kula\u011fa eri\u015fimde ya\u015fanan zorluklar\u0131 \u00f6\u011frendi\u011finde olduk\u00e7a \u015fa\u015f\u0131rd\u0131\u011f\u0131n\u0131 dile getiriyor: \u201cDoktorlar\u0131n insan v\u00fccudunun her yerine kolayca ula\u015f\u0131labilece\u011fini d\u00fc\u015f\u00fcn\u00fcrd\u00fcm.\u201d<\/em><\/p>\n

3D bask\u0131 ile gelen inovasyon<\/b><\/p>\n

<\/span> Ancak i\u00e7 kulak m\u00fchendislik a\u00e7\u0131s\u0131ndan ke\u015ffedilmemi\u015f bir b\u00f6lgeydi. Bu zorluk, Kysar\u2019\u0131 daha fazla ara\u015ft\u0131rmaya y\u00f6nlendirdi. Koklea zar\u0131n\u0131n inceliklerini anlamak ve uygun bir \u00e7\u00f6z\u00fcm geli\u015ftirmek i\u00e7in ileri \u00fcretim teknikleri kulland\u0131. Kysar ve ekibi, iki fotonlu fotolitografi<\/strong> (two-photon lithography) ad\u0131 verilen y\u00fcksek \u00e7\u00f6z\u00fcn\u00fcrl\u00fckl\u00fc 3D bask\u0131<\/strong> teknolojisini kullanarak insan sa\u00e7\u0131ndan daha ince bir mikroi\u011fne<\/strong> \u00fcretti. Bu teknoloji sayesinde mevcut t\u0131bbi i\u011fnelerden daha keskin ve dayan\u0131kl\u0131 bir cihaz ortaya \u00e7\u0131kt\u0131. <\/figure>\n

Geli\u015ftirilen mikroi\u011fne, zar \u00fczerinde yaln\u0131zca kendi \u00e7ap\u0131 kadar k\u00fc\u00e7\u00fck bir delik a\u00e7\u0131yor<\/strong> ve bu delik 48 saat i\u00e7inde kendili\u011finden iyile\u015fiyor<\/strong>. Hayvanlar \u00fczerinde yap\u0131lan testlerde, cihaz\u0131n i\u015fitme kayb\u0131na veya ba\u015fka olumsuz etkilere neden olmad\u0131\u011f\u0131 da g\u00f6zlemlendi. Gen terapisi i\u00e7in de uygun olan i\u011fnenin tasar\u0131m\u0131n\u0131geli\u015ftirmeye devam eden Lalwani ve Kysar, mikroi\u011fnelerinin potansiyeli konusunda iyimserler.<\/p>\n\n

Kaynak\u00a0 :\u00a0https:\/\/www.donanimhaber.com\/isitme-kaybi-tedavilerinde-3d-baskili-mikroigne-devrimi–185806<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

T\u0131p d\u00fcnyas\u0131 ve m\u00fchendislik alan\u0131nda \u00e7al\u0131\u015fan bir ekip, on y\u0131l\u0131 a\u015fk\u0131n s\u00fcredir y\u00fcr\u00fctt\u00fc\u011f\u00fc ara\u015ft\u0131rmalar sonucu i\u015fitme kayb\u0131 ve i\u00e7 kulak rahats\u0131zl\u0131klar\u0131n\u0131n tedavisinde devrim yaratacak bir mikroi\u011fne geli\u015ftirdi. Columbia \u00dcniversitesi\u2019nden Kulak Burun …<\/p>\n","protected":false},"author":1,"featured_media":124205,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[6721,66,357,8254],"class_list":["post-124204","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-teknoloji","tag-isitme","tag-kulak","tag-tedavi","tag-zar"],"_links":{"self":[{"href":"https:\/\/kamucalisani.net\/index.php\/wp-json\/wp\/v2\/posts\/124204","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kamucalisani.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kamucalisani.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kamucalisani.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kamucalisani.net\/index.php\/wp-json\/wp\/v2\/comments?post=124204"}],"version-history":[{"count":1,"href":"https:\/\/kamucalisani.net\/index.php\/wp-json\/wp\/v2\/posts\/124204\/revisions"}],"predecessor-version":[{"id":124209,"href":"https:\/\/kamucalisani.net\/index.php\/wp-json\/wp\/v2\/posts\/124204\/revisions\/124209"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kamucalisani.net\/index.php\/wp-json\/wp\/v2\/media\/124205"}],"wp:attachment":[{"href":"https:\/\/kamucalisani.net\/index.php\/wp-json\/wp\/v2\/media?parent=124204"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kamucalisani.net\/index.php\/wp-json\/wp\/v2\/categories?post=124204"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kamucalisani.net\/index.php\/wp-json\/wp\/v2\/tags?post=124204"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}