{"id":82685,"date":"2024-08-18T03:12:05","date_gmt":"2024-08-18T03:12:05","guid":{"rendered":"https:\/\/kamucalisani.net\/?p=82685"},"modified":"2024-08-18T03:12:05","modified_gmt":"2024-08-18T03:12:05","slug":"gelistirilen-yeni-deri-alti-implanti-asiri-dozdan-kaynaklanan-olum-riskini-ortadan-kaldirabilir","status":"publish","type":"post","link":"https:\/\/kamucalisani.net\/index.php\/2024\/08\/18\/gelistirilen-yeni-deri-alti-implanti-asiri-dozdan-kaynaklanan-olum-riskini-ortadan-kaldirabilir\/","title":{"rendered":"Geli\u015ftirilen yeni deri alt\u0131 implant\u0131, a\u015f\u0131r\u0131 dozdan kaynaklanan \u00f6l\u00fcm riskini ortadan kald\u0131rabilir"},"content":{"rendered":"

<\/span> Ha\u015fha\u015f bitkisinde bulunan do\u011fal maddelerden t\u00fcretilen bir ila\u00e7 s\u0131n\u0131f\u0131 olan opioidler<\/strong>, \u00f6nemli bir\u00e7ok hastal\u0131\u011f\u0131n tedavisinde kullan\u0131lmas\u0131na ra\u011fmen fazla kullan\u0131ld\u0131\u011f\u0131nda ba\u011f\u0131ml\u0131l\u0131k yapabilmekte. Sadece bununla kalmayan opioidler, a\u015f\u0131r\u0131 dozdan<\/strong> kaynaklanan \u00f6l\u00fcmlere de sebep olabilmekte. <\/figure>\n

A\u015f\u0131r\u0131 doz ald\u0131\u011f\u0131nda, m\u00fcmk\u00fcn olan en k\u0131sa s\u00fcrede opioid tersine \u00e7eviren bir ila\u00e7 olan nalokson <\/strong>almas\u0131 kritik derecede \u00f6nemlidir. \u00c7\u00fcnk\u00fc aksi takdirde \u00f6l\u00fcm riski \u00e7ok fazlad\u0131r<\/strong>. Ancak yak\u0131n zamanl\u0131 yeni bir \u00e7al\u0131\u015fma, naloksonu otomatik olarak v\u00fccudun i\u00e7inden da\u011f\u0131tarak bu soruna \u00e7\u00f6z\u00fcm bulmu\u015f olabilir.<\/p>\n

iSOS implant\u0131, a\u015f\u0131r\u0131 dozdan kaynaklanan riskleri ortadan kald\u0131rabilir<\/b><\/p>\n

Opioid G\u00fcvenli\u011fi i\u00e7in \u0130mplante Edilebilir Sistem’in<\/strong> k\u0131saltmas\u0131 olan iSOS implant\u0131,<\/strong> MIT ve Harvard’a ba\u011fl\u0131 Brigham and Women’s Hospital’dan<\/em> bir grup bilim insan\u0131 taraf\u0131ndan geli\u015ftirildi. Cihaz 78 mm uzunlu\u011funda, 12 mm geni\u015fli\u011finde ve 8 mm kal\u0131nl\u0131\u011f\u0131nda. B\u00fcnyesinde 10 miligram nalokson bulunduran implant, ayr\u0131ca pil, vibrat\u00f6r ve Bluetooth mod\u00fcl\u00fc gibi elektronik aksamlar\u0131n yan\u0131 s\u0131ra \u00e7oklu EKG elektrotlar\u0131 ve bir dizi ba\u015fka sens\u00f6r de bar\u0131nd\u0131rmakta.<\/p>\n

<\/span> Kar\u0131n bo\u015flu\u011fundaki sempatik sinir a\u011flar\u0131n\u0131n en b\u00fcy\u00fc\u011f\u00fc olan solar pleksus yak\u0131n\u0131ndaki derinin hemen alt\u0131na, lokal anestezi kullan\u0131larak yerle\u015ftirilen bu implant, yerle\u015ftirildikten sonra hastan\u0131n v\u00fccut \u0131s\u0131s\u0131n\u0131, kalp at\u0131\u015f h\u0131z\u0131n\u0131, solunum h\u0131z\u0131n\u0131 ve kandaki oksijen doygunlu\u011funu izleyebilmekte. Bu parametreler opioid doz a\u015f\u0131m\u0131n\u0131n ger\u00e7ekle\u015fti\u011fini<\/strong> g\u00f6sterecek \u015fekilde de\u011fi\u015firse, cihaz hem dokunsal hem de sesli bir uyar\u0131 \u00fcretmek i\u00e7in vibrat\u00f6r\u00fcn\u00fc etkinle\u015ftirecek. <\/figure>\n

Ayr\u0131ca hastan\u0131n ve acil durum irtibat ki\u015fisinin ak\u0131ll\u0131 telefonundaki uygulamaya bir uyar\u0131 g\u00f6nderen implant, yanl\u0131\u015f bir durumda uygulama arac\u0131l\u0131\u011f\u0131yla durmas\u0131 sa\u011flanabilir. Ancak bu hemen yap\u0131lmazsa iSOS, kan dola\u015f\u0131m\u0131na h\u0131zla bir doz nalokson pompalamaya devam eder.<\/p>\n

Laboratuvar testlerinde cihaz, a\u015f\u0131r\u0131 dozda fentanil alan domuzlar\u0131n %96’s\u0131n\u0131<\/strong> ortalama 3,2 dakika<\/strong> i\u00e7inde ba\u015far\u0131yla hayata d\u00f6nd\u00fcrd\u00fc. Bataryas\u0131 \u015fu anda 16 g\u00fcnl\u00fck<\/strong> ya\u015famsal belirti takibi i\u00e7in yeterli ve gerekti\u011finde kablosuz olarak yeniden \u015farj edilebiliyor. Son olarak implanttaki naloksonun bitmesi durumunda deri yoluyla implant\u0131n \u00fcst\u00fcndeki bir porta yerle\u015ftirilen bir hipodermik i\u011fne arac\u0131l\u0131\u011f\u0131yla yeniden doldurulabilir.<\/strong><\/p>\n\n

Kaynak\u00a0 :\u00a0https:\/\/www.donanimhaber.com\/yeni-deri-alti-implanti-asiri-doz-olumlerini-onleyebilir–180831<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"

Ha\u015fha\u015f bitkisinde bulunan do\u011fal maddelerden t\u00fcretilen bir ila\u00e7 s\u0131n\u0131f\u0131 olan opioidler, \u00f6nemli bir\u00e7ok hastal\u0131\u011f\u0131n tedavisinde kullan\u0131lmas\u0131na ra\u011fmen fazla kullan\u0131ld\u0131\u011f\u0131nda ba\u011f\u0131ml\u0131l\u0131k yapabilmekte. Sadece bununla kalmayan opioidler, a\u015f\u0131r\u0131 dozdan …<\/p>\n","protected":false},"author":1,"featured_media":82686,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[5054,5055],"class_list":["post-82685","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-teknoloji","tag-doz","tag-opioid"],"_links":{"self":[{"href":"https:\/\/kamucalisani.net\/index.php\/wp-json\/wp\/v2\/posts\/82685","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kamucalisani.net\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/kamucalisani.net\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/kamucalisani.net\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kamucalisani.net\/index.php\/wp-json\/wp\/v2\/comments?post=82685"}],"version-history":[{"count":1,"href":"https:\/\/kamucalisani.net\/index.php\/wp-json\/wp\/v2\/posts\/82685\/revisions"}],"predecessor-version":[{"id":82689,"href":"https:\/\/kamucalisani.net\/index.php\/wp-json\/wp\/v2\/posts\/82685\/revisions\/82689"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/kamucalisani.net\/index.php\/wp-json\/wp\/v2\/media\/82686"}],"wp:attachment":[{"href":"https:\/\/kamucalisani.net\/index.php\/wp-json\/wp\/v2\/media?parent=82685"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/kamucalisani.net\/index.php\/wp-json\/wp\/v2\/categories?post=82685"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/kamucalisani.net\/index.php\/wp-json\/wp\/v2\/tags?post=82685"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}